دانلود مقاله ترجمه شده مکانیسم و جنبه‌های بالینی اثرات کاسنی بر دیابت

Abstract

At  present,  there  is  no  cure  for  diabetes.  However,  due  to  the  side  effects  of  synthetic  drugs, medicinal plants, have been variously used to treat it. One such anti-diabetic plant is chicory.  The aim of this study is to review and summarize the clinical aspects and mechanisms of the effects of chicory  and  its  products  on  the  key  factors  involved  in  diabetes  in  different  environments. Accordingly, it seems chicory is effective in almost all tissues and organs involved in blood sugar control. For instance, chicory has been shown to (i) inhibit the breakdown of disaccharides in the gastrointestinal tract  and  glucose  absorption  in  the  intestine, (ii)  prevent the  release of  glucose from the liver, (iii) increase glucose uptake by the peripheral tissues, especially in muscles and the liver, (iv) stimulate insulin secretion from the pancreas, (v) enhance the insulin signaling pathways downstream  and  thereby  reduce  the  diabetic  complications.  Consequently,  blood  glucose reduction  after  the  administration  of  chicory  is  notable.  The  administration  of  chicory  products appeared to have short-term and/or long-term effects on diabetes. This claim is approved by the results from the glucose tolerance test and HbA1c measurement. In addition, chicory fights against some primary agents responsible for diabetes and obesity. Since chicory reduces blood glucose and it has anti-diabetic effects, it is recommended that the involved mechanisms be investigated.