دانلود مقاله ترجمه شده دیستروفی عضلانی دوشن: گزارش موردی و مرور

Abstract

Muscular dystrophies are a clinically and heterogeneous group of disorders that all share clinical characteristics of progressive muscular weakness. Duchenne muscular dystrophy (DMD) is the most common X‑linked disorder muscular dystrophy in children, presenting  in  early  childhood  and  characterized  by  proximal  muscle  weakness  and  calf  hypertrophy  in  affected  boys.  There  is  usually delay in motor development and eventually wheelchair confinement followed by premature death from cardiac or respiratory complications. Treatment modalities such as corticosteroid therapy and use of intermittent positive pressure ventilation have provided improvements in function, ambulation, quality of life, and life expectancy, although novel therapies still aim to provide a cure for this devastating disorder. Here, we present a case of DMD in a 12‑year‑old male with remarkable clinical and oral manifestations.